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Neuro Superfood

Prebiotic for Cognitive Support

Prebiotic blend containing mushrooms, fruits, oligosaccharides, and phytonutrients for cognitive and microbiome support.

  • Brain

    Brain

  • Gut

    Gut

  • Whole Body

    Whole Body

  • Immunity

    Immunity

Health Indications

  • Nourish Commensal Bacteria and Keystone Species Found in Neuro μBiomic
  • Enhance Microbiome Diversity
  • Boost Overall Health and Vitality
  • Support the Body's Vital Functions
  • Fight Diseases and Boost Immunity
  • Promote Proper Sleep Hygiene and Sleep Cycles
  • Reduce Feelings of Stress
  • Enhance Physical and Mental Health
  • Provide a Variety of Quality Fibers
  • Boost Brain and Cognitive Health
  • Maintain Mental Vitality
  • Improve Memory and Learning Capabilities
  • Balance Mood
  • Support a Healthy, Active Lifestyle
  • Promote Long-Term Health and Wellness

Instructions For Use

Mix 1 scoop with 8-16 oz of your desired liquid and consume daily, or as directed by your healthcare provider. Neuro Superfood can be taken with or without food.

Other fun ways to incorporate Neuro Superfood into your daily wellness routine include:

  • Add to a favorite smoothie
  • Mix with sparkling water for a homemade prebiotic soda

We highly recommend Neuro Superfood be paired with its synergistic probiotic formula, Neuro µBiomic, for unparalleled results and remarkable health benefits.

**Individual needs may vary; please consult your practitioner before altering the prescribed doses or protocols.

Product Description

Neuro Superfood - Product Description

Alimentum Labs leads in precision microbiome care by tailoring probiotics and prebiotics to specific health needs. Extensive research underscores the profound impact of diet on the microbiome’s diversity, highlighting the crucial role of diverse prebiotic fibers and superfoods. Our studies affirm the potent influence of unique phytochemicals like flavonoids, flavanols, cyanidins, procyanidins, terpenes, and alkaloids on the microbiome’s health.

Neuro Superfood - Product Description

In today’s fast-paced world, the importance of mental health and stress management is increasingly evident. A myriad of factors, including diet, gut dysbiosis, and sedentary lifestyles, compound this challenge. Processed foods high in sugar and unhealthy fats disrupt gut bacteria balance, while the stressful American lifestyle triggers the “fight or flight” response, affecting digestion. Antibiotic overuse further disrupts the gut microbiome, leading to enduring complications like diarrhea, IBS, and neurological disorders.

Most current commercial prebiotic approaches consist of ultra-small doses of 1 or 2 fibers or ingredients that most bacteria can utilize, including many harmful microbes. Meanwhile, Neuro Superfood transforms prebiotic approaches with its targeted blend of 17 powerful fruits, fibers, and mushrooms, supporting neuroprotective probiotics and the gut-brain microbiome. Designed to deliver essential phytonutrients, it enhances neuropsychological health and overall well-being. As part of our patent-pending system, Neuro Superfood stands as a versatile solution for daily wellness, free from artificial additives, and crafted for effectiveness.

Key Elements and Features of Neuro Superfood

  • Complementary Prebiotic to Neuro µBiomic Probiotic

    Neuro Superfood was designed to be taken alongside Neuro µBiomic. By nourishing and helping to colonize the keystone probiotics in Neuro μBiomic, this product promotes a thriving diverse microbiome, ensuring optimal neurological health and cognitive function.

  • Supports Restful Sleep

    Neuro Superfood is ideal for supporting natural circadian rhythms through a multifaceted approach. Nutrient rich plant fibers are metabolized by specific gut bacteria, such as those provided in Neuro μBiomic, and produce neuromodulating compounds. Other compounds provided in Neuro Superfood, like lion’s mane mushroom, directly calm and stabilize the nervous system.

  • Enhances Mood

    Neuro Superfood provides a precise blend of nutrients that boost mood by promoting balanced neurotransmitter levels, improving stress response, and enhancing energy levels. The premium combination of plant fibers, mushrooms, and neurodevelopmental proteins protects both the nervous system and the gut microbiome, while defending the complex relationship between them known as the gut-brain axis.

  • Ideal for Daily Wellness as a High Fiber Prebiotic

    Neuro Superfood contains eight grams of high-quality unique fibers, including both soluble and insoluble fiber, each with specialized functions. These functions include supporting neurological health, cognitive function, and positive mood, as well as promoting a healthy gut microbiome. Consuming a variety of fibers is essential for full-body wellness, as the gut microbiome serves as the connection to numerous body systems and functions. By consuming Neuro Superfood, the health of the gut positively reinforces the gut-brain axis and overall wellness.

Prebiotic and Superfoods Spotlight

Brain Enhancing Blend

Rich in a variety of plant fibers, this blend of prebiotics and superfoods was designed using quality, research-backed components. The fruits, such as gold kiwi which significantly increases levels of neuroprotective keystone bacteria in the gut, and raspberry which enhances cognitive performance and reduces the risk of neurodegeneration while also supporting important symbiotic bacteria in the gut microbiome, were selected for their neuroprotective properties. The potent mushroom blend, a component typically acquired separately and at a much higher cost, was included here for full spectrum support and offers powerful effects in optimizing neurotransmitter levels, balancing mood, and improving memory and learning ability. Improving neurocognitive health through the gut microbiome and inherent neural pathways sets Neuro Superfood apart as a critical component of a comprehensive nutritional regimen.

Immune Balance Blend

A crucial component to Neuro Superfood’s efficacy is the addition of proteins that modulate the immune system to benefit neurocognitive functions. Clinical studies have shown that IgY supplementation enhances memory and cognitive function, while lactoferrin supplementation encourages appropriate immune system and brain development. Both of these additions have been suggested to enhance pharmaceutical effects for individuals already experiencing cognitive decline. For these reasons, IgY and lactoferrin were included to benefit those of all ages and mental stages.

How Neuro Superfood Works

Neuro Superfood supports neurological wellness with its nutrient-dense and diverse formula of plant fibers, polyphenols, flavonoids, mushroom-based neurocognitive enhancers, and neuroprotective proteins. A portion of these ingredients, such as the plant fibers, inherently support the growth of exclusive probiotics found in Alimentum Labs’ complimentary Neuro μBiomic product and the gut microbiome as a whole. The other portion of ingredients enhance neurocognitive function, mood stability, and proper nervous system recovery through direct neuromodulation. With Neuro Superfood, you are not only supporting a healthy and diverse gut microbiome, you are also enhancing your overall well-being.

How It Works

Key Ingredients

Pomegranate Ext. (Ellagitannin)

The ellagitannins in pomegranate are dietary polyphenols that are poorly absorbed but used extensively as prebiotics by the human gut microbiome to produce urolithins.1 It has been suggested that Urolithin A may exhibit a neuroprotective effect by inhibiting DYRK1A activity.2 Pomegranate also raises Lactobacillus levels in the gut, including L. acidophilus and L. plantarum found in Neuro µBiomic.3

Raspberry Pwd. (Gallic & Ellagic Acid)

Raspberries are a natural powerhouse of dietary fiber and many beneficial antioxidants and compounds, including several flavonoids and polyphenols, such as gallic acid and ellagic acid.4,5 Gallic acid is a natural polyphenolic flavonoid that has demonstrated many neuroprotective properties.6 Ellagic acid has been shown to enhance cognitive function by increasing brain-derived neurotrophic factor (BDNF) levels in plasma, reducing saliva cortisol levels, and improving blood lipid metabolism.7

Gold Kiwi (Livaux®)

Gold kiwifruit is clinically proven to specifically increase Faecalibacterium prausnitzii, one of Alimentum Labs’ exclusive keystone probiotics found in Neuro µBiomic.8 Gold kiwifruit has high levels of polyphenols including cinnamic acids (E-caffeoyl-3-glucoside and neochlorogenic acid) and flavanols (procyanidin B2 and epicatechin).9 Gold kiwi also provides both soluble and insoluble fibers to support microbiome balance while being one of the most nutrient-dense fruits in the world.10

Green Kiwi (Actazin®)

Actazin® may help prevent or relieve constipation and has been proven to benefit bowel regularity and stool softness in two clinical trials.11,12 Green kiwifruit contains a unique digestive enzyme, actinidin, which greatly enhances protein digestion, reducing gastric discomfort and bloating associated with poorly digested protein.13–15 The complex dietary fiber of kiwifruit has superior water retention capacity (twice as much as apples and four times as much as wheat bran), which contributes to smooth bowel movements.16 The complexity of kiwifruit fiber also ferments slowly, preventing excess gas and bloating associated with many prebiotics.16

Phyllanthus niruri (Geraniin & Furosin)

P. niruri, also known as Chanca Piedra, is a tropical plant long used in Ayurvedic medicine.17 P. niruri contains numerous flavonoids such as gallocatechin, quercetin and kaempferol.17 It is also a good source of rare ellagitannins such as geraniin and furosin.17 Geraniin has shown great potential as a prebiotic to combat high-fat diet induced metabolic syndrome.18 Additionally, geraniin may exert a neuroprotective effect by suppressing oxidative stress and neuronal apoptosis.19 Another study showed geraniin targeting TLR4-mediated signaling to decrease proinflammatory cytokines and mitigates lipopolysaccharide-elicited neurodegeneration and cognitive impairment.20 Furosin also exhibits anti-inflammatory and neuroprotective effects.21

Sorghum

Sorghum grain is a highly nutritious cereal that contains mixed polyphenols and is one of the highest food sources of proanthocyanidins.22 One study reported that sorghum polyphenols worked with fructo-oligosaccharides (FOS) to enhance Bifidobacterium and Lactobacillus genera, such as those found in Neuro µBiomic, and independently increased the beneficial Roseburia and Prevotella genera as well.23

Fructo-oligosaccharides (FOS)

Fructo-oligosaccharides (FOS) are oligosaccharides that occur naturally in plants such as onion, chicory, garlic, asparagus, banana, artichoke, among many others.24 Diets enriched with FOS increase the levels of Alimentum Labs’ exclusive keystone probiotics F. prausnitzii and Parabacteroides distasonis.25,26 Supplementation of FOS along with Alimentum Labs’ exclusive keystone probiotic Agathobaculum butyriciproducens (found in Neuro µBiomic) has been shown to increase microbiome diversity and improve healthy microbiome composition.27

Galacto-oligosaccharides (OSG)

GOS are a type of plant fiber that are not digestible by the human gut. Instead, they are specifically intended for consumption by symbiotic gut bacteria. Consuming GOS significantly increases populations of neuroprotective bacteria like P. distasonis28 and Bifidobacterium species.29 Additionally, GOS are particularly useful because they cannot be consumed by pathogenic bacteria, which helps prevent these populations from taking root in the gut microbiome.30

Isomalto-oligosaccharides (IMO)

IMOs are one of the most promising prebiotics among all oligosaccharides.31 IMOs have the demonstrated ability to significantly raise beneficial Bifidobacterium, Lactobacillus, and Bacteroides counts while decreasing harmful Clostridium levels.32

Pectin (Apple)

F. prausnitzii strains possess some ability to utilize apple pectin.33 Pectin has also shown the ability to increase the relative abundance of Bacteroides, Parabacteroides, and Bifidobacterium.34 Moreover, many studies have found that apple pectin can help suppress weight gain, modify gut microbiota, protect gut barriers, and reduce oxidative stress.35–37

Blueberry

Blueberries are well known for their health benefits, among which include the antioxidant neuroprotective powers of blueberry polyphenols.38 Blueberries contain high levels of polyphenols that include anthocyanins, flavanol glycosides and proanthocyanidins.39 Blueberry polyphenols have been proven to increase beneficial bacteria in the microbiome, including F. prausnitzii.39 Furthermore, it has been reported that the benefits of blueberry polyphenols are boosted by Lactiplantibacillus plantarum and Bifidobacterium bifidum.40,41

Blackcurrant

The flavonoid- and anthocyanin-rich blackcurrant (Ribes nigrum) has shown neuroprotective effects.42 Blackcurrant has also clinically shown the ability to improve cognition through the inhibition of MAO-A and MAO-B (monoamine oxidase).43 L. plantarum and other lactobacilli possess the ability to amplify the antioxidant and polyphenolic benefits of blackcurrants.44

Deoxynojirimycin Polysaccharides (DPM) (from Morus alba)

Deoxynojirimycin polysaccharides are complex carbohydrates found in mulberry leaves. They are most well-known for their ability to inhibit α-glucosidase, aiding in blood sugar regulation.45,46 Additionally, recent studies have suggested DMP may play a neuroprotective role.47,48

Karaya Gum

Derived from trees of the Sterculia genus and used in African and Ayurvedic medicine, karaya gum easily absorbs water, swelling up to 60 times the original volume, and functions like an insoluble fiber, supporting regular bowel movements.49,50

Guggul Ext. (Guggulipids)

An Ayurvedic prebiotic with a long history of supporting neurological balance, normal cholesterol synthesis activities, and healthy skin.51

Lion’s Mane Mushroom (Hericium erinaceus)

Hericium erinaceus, also known as lion’s mane mushroom, enhances peripheral nerve regeneration by targeting nerve growth factor (NGF) activity.52 Compounds found in lion’s mane mushroom, such as N-de phenylethyl isohericerin (NDPIH) and hericene A, demonstrate potent neurotrophic effects, promoting axon outgrowth and neurite branching independently of tropomyosin receptor kinase B (TrkB) and through a complementary ERK1/2 activation pathway, leading to enhanced cognitive performance. Studies have shown that oral supplementation of H. erinaceus reduces symptoms of depression, anxiety, and sleep disorders, improves mood and quality of sleep, and increases levels of circulating pro-BDNF (brain-derived neurotrophic factor), potentially benefiting overall mental health and cognitive function in both healthy individuals and those with mood disorders.53,54

Cordyceps militaris

C. militaris is a species of fungus that has recently received attention for its wide variety of health benefits, including boosting longevity, exercise performance, and mood. It produces a compound known as cordycepin, which is believed to play a role in its ability to modulate serotonin and dopamine levels. C. militaris enhances Lactobacillus (beneficial bacteria) and reduces Rothia and Actinomyces (harmful bacteria), suggesting that its peptides and polysaccharides have the ability to regulate gut microbiota.55 Some studies have also shown C. militaris to have neuroprotective effects and enhance learning and memory.56

Immunoglobulin Y (IgY)

IgY, or immunoglobulin Y, is a type of antibody found in the yolks of bird eggs, typically chicken or duck eggs. Studies have shown that IgY supplementation improves memory and overall cognitive performance. The proposed mechanism through which these benefits occur is the activation of the (cAMP/PKA) and (PI3K/Akt) pathways, which protect neurons and their activity levels. It has been proposed as a safe addition or alternative to cognition-enhancing pharmaceutical medications.57

Lactoferrin

Lactoferrin, a protein present abundantly in milk and especially in human breast milk, plays vital roles in both brain and immune system development. Recent studies have explored its protective potential against neurodegeneration. Lactoferrin binds iron atoms, which protects the brain and nervous system from oxidative damage.58,59 Additionally, lactoferrin can easily cross the blood-brain barrier, and when bound to other pharmaceuticals, it may allow these pharmaceuticals to achieve greater access to the brain, offering an improved therapeutic effect.60

Warnings/Contraindications

When used as directed, there are no known contraindications for Neuro Superfood.

**It is always recommended that you consult your practitioner prior to adding any new supplement to your regimen if you are pregnant, breastfeeding, experiencing renal failure, undergoing an organ transplant(s), managing diabetes with insulin, or are taking medication(s) for any pre-existing conditions.**

Safety

All ingredients are tested before use for:

  • Pathogenic microbial contaminants
  • Heavy metals and/or chemical contaminants
  • Correct genus and species of probiotic microbes
  • Purity

Additional Information

  • Gluten Free
  • No Sugar
  • Non-GMO
  • cGMP Facility
  • Vegetarian

References

  1. García-Villalba, R.; Tomás-Barberán, F. A.; Iglesias-Aguirre, C. E.; Giménez-Bastida, J. A.; González-Sarrías, A.; Selma, M. V.; Espín, J. C. Ellagitannins, Urolithins, and Neuroprotection: Human Evidence and the Possible Link to the Gut Microbiota. Mol. Aspects Med. 2023, 89, 101109. https://doi.org/10.1016/j.mam.2022.101109.
  2. Tu, H.-J.; Su, C.-J.; Peng, C.-S.; Lin, T. E.; HuangFu, W.-C.; Hsu, K.-C.; Hwang, T.-L.; Pan, S.-L. Urolithin A Exhibits a Neuroprotective Effect against Alzheimer’s Disease by Inhibiting DYRK1A Activity. J. Food Drug Anal. 2023, 31 (2), 358–370. https://doi.org/10.38212/2224-6614.3462.
  3. O’Flaherty, S.; Cobian, N.; Barrangou, R. Impact of Pomegranate on Probiotic Growth, Viability, Transcriptome and Metabolism. Microorganisms 2023, 11 (2), 404. https://doi.org/10.3390/microorganisms11020404.
  4. Chen, L.; Xin, X.; Zhang, H.; Yuan, Q. Phytochemical Properties and Antioxidant Capacities of Commercial Raspberry Varieties. J. Funct. Foods 2013, 5 (1), 508–515. https://doi.org/10.1016/j.jff.2012.10.009.
  5. Núñez-Gómez, V.; Periago, M. J.; Navarro-González, I.; Campos-Cava, M. P.; Baenas, N.; González-Barrio, R. Influence of Raspberry and Its Dietary Fractions on the In Vitro Activity of the Colonic Microbiota from Normal and Overweight Subjects. Plant Foods Hum. Nutr. Dordr. Neth. 2021, 76 (4), 494–500. https://doi.org/10.1007/s11130-021-00923-6.
  6. Kahkeshani, N.; Farzaei, F.; Fotouhi, M.; Alavi, S. S.; Bahramsoltani, R.; Naseri, R.; Momtaz, S.; Abbasabadi, Z.; Rahimi, R.; Farzaei, M. H.; Bishayee, A. Pharmacological Effects of Gallic Acid in Health and Diseases: A Mechanistic Review. Iran. J. Basic Med. Sci. 2019, 22 (3), 225–237. https://doi.org/10.22038/ijbms.2019.32806.7897.
  7. Liu, Y.; Yu, S.; Wang, F.; Yu, H.; Li, X.; Dong, W.; Lin, R.; Liu, Q. Chronic Administration of Ellagic Acid Improved the Cognition in Middle-Aged Overweight Men. Appl. Physiol. Nutr. Metab. 2018, 43 (3), 266–273. https://doi.org/10.1139/apnm-2017-0583.
  8. Blatchford, P.; Stoklosinski, H.; Eady, S.; Wallace, A.; Butts, C.; Gearry, R.; Gibson, G.; Ansell, J. Consumption of Kiwifruit Capsules Increases Faecalibacterium Prausnitzii Abundance in Functionally Constipated Individuals: A Randomised Controlled Human Trial. J. Nutr. Sci. 2017, 6, e52. https://doi.org/10.1017/jns.2017.52.
  9. Dawes, H. M.; Keene, J. B. Phenolic Composition of Kiwifruit Juice. J. Agric. Food Chem. 1999, 47 (6), 2398–2403. https://doi.org/10.1021/jf9810261.
  10. Richardson, D. P.; Ansell, J.; Drummond, L. N. The Nutritional and Health Attributes of Kiwifruit: A Review. Eur. J. Nutr. 2018, 57 (8), 2659–2676. https://doi.org/10.1007/s00394-018-1627-z.
  11. Ansell, J.; Butts, C. A.; Paturi, G.; Eady, S. L.; Wallace, A. J.; Hedderley, D.; Gearry, R. B. Kiwifruit-Derived Supplements Increase Stool Frequency in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Nutr. Res. N. Y. N 2015, 35 (5), 401–408. https://doi.org/10.1016/j.nutres.2015.04.005.
  12. Lewis, E. D.; Graham, E.; McKeen, S.; Li, Z.; Henning, S. M.; Jopson, N.; Gu, J.; Rosendale, D.; Evans, M. Actazin® Green Kiwifruit Powder Consumption at 600 Mg per Day for 28 Days Improves Stool Form and Relieves Occasional Constipation in Healthy Individuals: A Randomized Controlled Trial., 2024. https://actazin.com/science-story/.
  13. Park, S.; Church, D. D.; Starck, C.; Schutzler, S. E.; Azhar, G.; Kim, I.-Y.; Ferrando, A. A.; Moughan, P. J.; Wolfe, R. R. The Impact of Hayward Green Kiwifruit on Dietary Protein Digestion and Protein Metabolism. Eur. J. Nutr. 2021, 60 (2), 1141–1148. https://doi.org/10.1007/s00394-020-02363-5.
  14. Wallace, A.; Eady, S.; Drummond, L.; Hedderley, D.; Ansell, J.; Gearry, R. A Pilot Randomized Cross-Over Trial to Examine the Effect of Kiwifruit on Satiety and Measures of Gastric Comfort in Healthy Adult Males. Nutrients 2017, 9 (7), 639. https://doi.org/10.3390/nu9070639.
  15. Kaur, L.; Rutherfurd, S. M.; Moughan, P. J.; Drummond, L.; Boland, M. J. Actinidin Enhances Gastric Protein Digestion as Assessed Using an in Vitro Gastric Digestion Model. J. Agric. Food Chem. 2010, 58 (8), 5068–5073. https://doi.org/10.1021/jf903332a.
  16. Sims, I. M.; Monro, J. A. Fiber: Composition, Structures, and Functional Properties. Adv. Food Nutr. Res. 2013, 68, 81–99. https://doi.org/10.1016/B978-0-12-394294-4.00005-5.
  17. Mediani, A.; Abas, F.; Maulidiani, M.; Khatib, A.; Tan, C. P.; Safinar Ismail, I.; Shaari, K.; Ismail, A. Characterization of Metabolite Profile in Phyllanthus Niruri and Correlation with Bioactivity Elucidated by Nuclear Magnetic Resonance Based Metabolomics. Mol. J. Synth. Chem. Nat. Prod. Chem. 2017, 22 (6), 902. https://doi.org/10.3390/molecules22060902.
  18. Moorthy, M.; Wie, C. C.; Mariño, E.; Palanisamy, U. D. The Prebiotic Potential of Geraniin and Geraniin-Enriched Extract against High-Fat-Diet-Induced Metabolic Syndrome in Sprague Dawley Rats. Antioxidants 2022, 11 (4), 632. https://doi.org/10.3390/antiox11040632.
  19. Yang, Y.; He, B.; Zhang, X.; Yang, R.; Xia, X.; Chen, L.; Li, R.; Shen, Z.; Chen, P. Geraniin Protects against Cerebral Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Neuronal Apoptosis via Regulation of the Nrf2/HO-1 Pathway. Oxid. Med. Cell. Longev. 2022, 2022, 2152746. https://doi.org/10.1155/2022/2152746.
  20. Wang, D.; Dong, X.; Wang, B.; Liu, Y.; Li, S. Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation. J. Agric. Food Chem. 2019, 67 (36), 10079–10088. https://doi.org/10.1021/acs.jafc.9b03977.
  21. Hossain, M. T.; Matin, A.; Tabassum, F.; Rashid, H. A. A Review Study On The Pharmacological Effects And Mechanism Of Action Of Tannins. Eur. J. Pharm. Med. Res. 2021, 8 (8).
  22. Luca, S. V.; Macovei, I.; Bujor, A.; Miron, A.; Skalicka-Woźniak, K.; Aprotosoaie, A. C.; Trifan, A. Bioactivity of Dietary Polyphenols: The Role of Metabolites. Crit. Rev. Food Sci. Nutr. 2020, 60 (4), 626–659. https://doi.org/10.1080/10408398.2018.1546669.
  23. Ashley, D.; Marasini, D.; Brownmiller, C.; Lee, J. A.; Carbonero, F.; Lee, S.-O. Impact of Grain Sorghum Polyphenols on Microbiota of Normal Weight and Overweight/Obese Subjects during In Vitro Fecal Fermentation. Nutrients 2019, 11 (2). https://doi.org/10.3390/nu11020217.
  24. Sabater-Molina, M.; Larqué, E.; Torrella, F.; Zamora, S. Dietary Fructooligosaccharides and Potential Benefits on Health. J. Physiol. Biochem. 2009, 65 (3), 315–328. https://doi.org/10.1007/BF03180584.
  25. Fagundes, R. R.; Bourgonje, A. R.; Saeed, A.; Vich Vila, A.; Plomp, N.; Blokzijl, T.; Sadaghian Sadabad, M.; von Martels, J. Z. H.; van Leeuwen, S. S.; Weersma, R. K.; Dijkstra, G.; Harmsen, H. J. M.; Faber, K. N. Inulin-Grown Faecalibacterium Prausnitzii Cross-Feeds Fructose to the Human Intestinal Epithelium. Gut Microbes 2021, 13 (1), 1993582. https://doi.org/10.1080/19490976.2021.1993582.
  26. Kang, S.; You, H. J.; Lee, Y.-G.; Jeong, Y.; Johnston, T. V.; Baek, N.-I.; Ku, S.; Ji, G. E. Production, Structural Characterization, and In Vitro Assessment of the Prebiotic Potential of Butyl-Fructooligosaccharides. Int. J. Mol. Sci. 2020, 21 (2), 445. https://doi.org/10.3390/ijms21020445.
  27. Ambat, A.; Antony, L.; Maji, A.; Ghimire, S.; Mattiello, S.; Kashyap, P. C.; More, S.; Sebastian, V.; Scaria, J. Enhancing Recovery from Gut Microbiome Dysbiosis and Alleviating DSS-Induced Colitis in Mice with a Consortium of Rare Short-Chain Fatty Acid-Producing Bacteria. bioRxiv February 26, 2024, p 2023.09.11.556543. https://doi.org/10.1101/2023.09.11.556543.
  28. Bowers, S. J.; Summa, K. C.; Thompson, R. S.; González, A.; Vargas, F.; Olker, C.; Jiang, P.; Lowry, C. A.; Dorrestein, P. C.; Knight, R.; Wright, K. P.; Fleshner, M.; Turek, F. W.; Vitaterna, M. H. A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats. Front. Neurosci. 2022, 16. https://doi.org/10.3389/fnins.2022.889211.
  29. Liu, F.; Li, P.; Chen, M.; Luo, Y.; Prabhakar, M.; Zheng, H.; He, Y.; Qi, Q.; Long, H.; Zhang, Y.; Sheng, H.; Zhou, H. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in Healthy Young Population. Sci. Rep. 2017, 7 (1), 11789. https://doi.org/10.1038/s41598-017-10722-2.
  30. Zeng, M.; van Pijkeren, J.-P.; Pan, X. Gluco-Oligosaccharides as Potential Prebiotics: Synthesis, Purification, Structural Characterization, and Evaluation of Prebiotic Effect. Compr. Rev. Food Sci. Food Saf. 2023, 22 (4), 2611–2651. https://doi.org/10.1111/1541-4337.13156.
  31. Tiangpook, S.; Nhim, S.; Prangthip, P.; Pason, P.; Tachaapaikoon, C.; Ratanakhanokchai, K.; Waeonukul, R. Production of a Series of Long-Chain Isomaltooligosaccharides from Maltose by Bacillus Subtilis AP-1 and Associated Prebiotic Properties. Foods 2023, 12 (7), 1499. https://doi.org/10.3390/foods12071499.
  32. Yen, C.-H.; Tseng, Y.-H.; Kuo, Y.-W.; Lee, M.-C.; Chen, H.-L. Long-Term Supplementation of Isomalto-Oligosaccharides Improved Colonic Microflora Profile, Bowel Function, and Blood Cholesterol Levels in Constipated Elderly People—A Placebo-Controlled, Diet-Controlled Trial. Nutrition 2011, 27 (4), 445–450. https://doi.org/10.1016/j.nut.2010.05.012.
  33. Chung, W. S. F.; Meijerink, M.; Zeuner, B.; Holck, J.; Louis, P.; Meyer, A. S.; Wells, J. M.; Flint, H. J.; Duncan, S. H. Prebiotic Potential of Pectin and Pectic Oligosaccharides to Promote Anti-Inflammatory Commensal Bacteria in the Human Colon. FEMS Microbiol. Ecol. 2017, 93 (11), fix127. https://doi.org/10.1093/femsec/fix127.
  34. Zhao, Y.; Bi, J.; Yi, J.; Peng, J.; Ma, Q. Dose-Dependent Effects of Apple Pectin on Alleviating High Fat-Induced Obesity Modulated by Gut Microbiota and SCFAs. Food Sci. Hum. Wellness 2022, 11 (1), 143–154. https://doi.org/10.1016/j.fshw.2021.07.015.
  35. Jiang, T.; Gao, X.; Wu, C.; Tian, F.; Lei, Q.; Bi, J.; Xie, B.; Wang, H. Y.; Chen, S.; Wang, X. Apple-Derived Pectin Modulates Gut Microbiota, Improves Gut Barrier Function, and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity. Nutrients 2016, 8 (3), 126. https://doi.org/10.3390/nu8030126.
  36. Chen, L.; Liu, L.; Li, C.; Hu, C.; Su, F.; Liu, R.; Zeng, M.; Zhao, D.; Liu, J.; Guo, Y.; Long, J. A Mix of Apple Pomace Polysaccharide Improves Mitochondrial Function and Reduces Oxidative Stress in the Liver of High-Fat Diet-Induced Obese Mice. Mol. Nutr. Food Res. 2017, 61 (3), 1600433. https://doi.org/10.1002/mnfr.201600433.
  37. Samout, N.; Bouzenna, H.; Dhibi, S.; Ncib, S.; ElFeki, A.; Hfaiedh, N. Therapeutic Effect of Apple Pectin in Obese Rats. Biomed. Pharmacother. 2016, 83, 1233–1238. https://doi.org/10.1016/j.biopha.2016.08.038.
  38. Giacalone, M.; Di Sacco, F.; Traupe, I.; Topini, R.; Forfori, F.; Giunta, F. Antioxidant and Neuroprotective Properties of Blueberry Polyphenols: A Critical Review. Nutr. Neurosci. 2011, 14 (3), 119–125. https://doi.org/10.1179/1476830511Y.0000000007.
  39. Ntemiri, A.; Ghosh, T. S.; Gheller, M. E.; Tran, T. T. T.; Blum, J. E.; Pellanda, P.; Vlckova, K.; Neto, M. C.; Howell, A.; Thalacker-Mercer, A.; O’Toole, P. W. Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers. Nutrients 2020, 12 (9), 2800. https://doi.org/10.3390/nu12092800.
  40. Wu, Y.; Li, S.; Tao, Y.; Li, D.; Han, Y.; Show, P. L.; Wen, G.; Zhou, J. Fermentation of Blueberry and Blackberry Juices Using Lactobacillus Plantarum, Streptococcus Thermophilus and Bifidobacterium Bifidum: Growth of Probiotics, Metabolism of Phenolics, Antioxidant Capacity in Vitro and Sensory Evaluation. Food Chem. 2021, 348, 129083. https://doi.org/10.1016/j.foodchem.2021.129083.
  41. Zhang, Y.; Liu, W.; Wei, Z.; Yin, B.; Man, C.; Jiang, Y. Enhancement of Functional Characteristics of Blueberry Juice Fermented by Lactobacillus Plantarum. LWT 2021, 139, 110590. https://doi.org/10.1016/j.lwt.2020.110590.
  42. Téglás, T.; Mihok, E.; Cziáky, Z.; Oláh, N.-K.; Nyakas, C.; Máthé, E. The Flavonoid Rich Black Currant (Ribes Nigrum) Ethanolic Gemmotherapy Extract Elicits Neuroprotective Effect by Preventing Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study. Molecules 2023, 28 (8), 3571. https://doi.org/10.3390/molecules28083571.
  43. Watson, A. W.; Haskell-Ramsay, C. F.; Kennedy, D. O.; Cooney, J. M.; Trower, T.; Scheepens, A. Acute Supplementation with Blackcurrant Extracts Modulates Cognitive Functioning and Inhibits Monoamine Oxidase-B in Healthy Young Adults. J. Funct. Foods 2015, 17, 524–539. https://doi.org/10.1016/j.jff.2015.06.005.
  44. Kowalski, R.; Miller, M. J.; Jawde, D.; Xie, Z.; Gonzalez de Mejia, E. Effect of Fermentation on Phenolic Composition and Antioxidant Capacity of Blackcurrant Juice Using Lactobacillus with Different SS-Glucosidase Activities. In Hispanic Foods: Chemistry of Fermented Foods; ACS Symposium Series; American Chemical Society, 2022; Vol. 1406, pp 91–113. https://doi.org/10.1021/bk-2022-1406.ch007.
  45. Kimura, T.; Nakagawa, K.; Kubota, H.; Kojima, Y.; Goto, Y.; Yamagishi, K.; Oita, S.; Oikawa, S.; Miyazawa, T. Food-Grade Mulberry Powder Enriched with 1-Deoxynojirimycin Suppresses the Elevation of Postprandial Blood Glucose in Humans. J. Agric. Food Chem. 2007, 55 (14), 5869–5874. https://doi.org/10.1021/jf062680g.
  46. Shahana, S.; Nikalje, A. P. G. Phytochemistry and Bioactivity of Morus Alba (Mulberry) Plant: A Comprehensive Review. Asian J. Pharm. Pharmacol. 2019, 5 (2), 207–217. https://doi.org/10.31024/ajpp.2019.5.2.1.
  47. Chen, W.; Liang, T.; Zuo, W.; Wu, X.; Shen, Z.; Wang, F.; Li, C.; Zheng, Y.; Peng, G. Neuroprotective Effect of 1-Deoxynojirimycin on Cognitive Impairment, β-Amyloid Deposition, and Neuroinflammation in the SAMP8 Mice. Biomed. Pharmacother. Biomedecine Pharmacother. 2018, 106, 92–97. https://doi.org/10.1016/j.biopha.2018.06.106.
  48. Jiang, Y.-G.; Wang, C.-Y.; Jin, C.; Jia, J.-Q.; Guo, X.; Zhang, G.-Z.; Gui, Z.-Z. Improved 1-Deoxynojirimycin (DNJ) Production in Mulberry Leaves Fermented by Microorganism. Braz. J. Microbiol. 2014, 45 (2), 721–729.
  49. Prasad, N.; Thombare, N.; Sharma, S. C.; Kumar, S. Production, Processing, Properties and Applications of Karaya (Sterculia Species) Gum. Ind. Crops Prod. 2022, 177, 114467. https://doi.org/10.1016/j.indcrop.2021.114467.
  50. Verbeken, D.; Dierckx, S.; Dewettinck, K. Exudate Gums: Occurrence, Production, and Applications. Appl. Microbiol. Biotechnol. 2003, 63 (1), 10–21. https://doi.org/10.1007/s00253-003-1354-z.
  51. Kunnumakkara, A. B.; Banik, K.; Bordoloi, D.; Harsha, C.; Sailo, B. L.; Padmavathi, G.; Roy, N. K.; Gupta, S. C.; Aggarwal, B. B. Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases. Front. Pharmacol. 2018, 9, 686. https://doi.org/10.3389/fphar.2018.00686.
  52. Martínez-Mármol, R.; Chai, Y.; Conroy, J. N.; Khan, Z.; Hong, S.-M.; Kim, S. B.; Gormal, R. S.; Lee, D. H.; Lee, J. K.; Coulson, E. J.; Lee, M. K.; Kim, S. Y.; Meunier, F. A. Hericerin Derivatives Activates a Pan-Neurotrophic Pathway in Central Hippocampal Neurons Converging to ERK1/2 Signaling Enhancing Spatial Memory. J. Neurochem. 2023, 165 (6), 791–808. https://doi.org/10.1111/jnc.15767.
  53. Vigna, L.; Morelli, F.; Agnelli, G. M.; Napolitano, F.; Ratto, D.; Occhinegro, A.; Di Iorio, C.; Savino, E.; Girometta, C.; Brandalise, F.; Rossi, P. Hericium Erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evid. Based Complement. Alternat. Med. 2019, 2019, e7861297. https://doi.org/10.1155/2019/7861297.
  54. Docherty, S.; Doughty, F. L.; Smith, E. F. The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients 2023, 15 (22), 4842. https://doi.org/10.3390/nu15224842.
  55. Wu, S.; Wu, Z.; Chen, Y. Effect of Cordyceps Militaris Powder Prophylactic Supplementation on Intestinal Mucosal Barrier Impairment and Microbiota-Metabolites Axis in DSS-Injured Mice. Nutrients 2023, 15 (20), 4378. https://doi.org/10.3390/nu15204378.
  56. Kim, Y. O.; Kim, H. J.; Abu-Taweel, G. M.; Oh, J.; Sung, G.-H. Neuroprotective and Therapeutic Effect of Cordyceps Militaris on Ischemia-Induced Neuronal Death and Cognitive Impairments. Saudi J. Biol. Sci. 2019, 26 (7), 1352–1357. https://doi.org/10.1016/j.sjbs.2018.08.011.
  57. Kazana, W.; Jakubczyk, D.; Siednienko, J.; Zambrowicz, A.; Macała, J.; Zabłocka, A. Mechanism of Molecular Activity of Yolkin—a Polypeptide Complex Derived from Hen Egg Yolk—in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7. Mol. Neurobiol. 2023, 60 (5), 2819–2831. https://doi.org/10.1007/s12035-023-03246-6.
  58. Eker, F.; Bolat, E.; Pekdemir, B.; Duman, H.; Karav, S. Lactoferrin: Neuroprotection against Parkinson’s Disease and Secondary Molecule for Potential Treatment. Front. Aging Neurosci. 2023, 15, 1204149. https://doi.org/10.3389/fnagi.2023.1204149.
  59. Xu, S.-F.; Zhang, Y.-H.; Wang, S.; Pang, Z.-Q.; Fan, Y.-G.; Li, J.-Y.; Wang, Z.-Y.; Guo, C. Lactoferrin Ameliorates Dopaminergic Neurodegeneration and Motor Deficits in MPTP-Treated Mice. Redox Biol. 2019, 21, 101090. https://doi.org/10.1016/j.redox.2018.101090.
  60. Yu, Y.; Jiang, X.; Gong, S.; Feng, L.; Zhong, Y.; Pang, Z. The Proton Permeability of Self-Assembled Polymersomes and Their Neuroprotection by Enhancing a Neuroprotective Peptide across the Blood–Brain Barrier after Modification with Lactoferrin. Nanoscale 2014, 6 (6), 3250–3258. https://doi.org/10.1039/C3NR05196J.
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